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04079cam a2200505Ia 4500 |
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on1164582219 |
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OCoLC |
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20210423014352.0 |
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m o d |
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200714s2020 sz o 001 0 eng d |
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|a YDX
|b eng
|c YDX
|d OPELS
|d OCLCF
|d ABC
|d OCLCO
|d EBLCP
|d OCLCA
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| 019 |
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|a 1175912891
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| 020 |
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|a 9780128200193
|q (electronic bk.)
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|a 0128200197
|q (electronic bk.)
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|z 0128200189
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|z 9780128200186
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| 035 |
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|a (OCoLC)1164582219
|z (OCoLC)1175912891
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| 050 |
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4 |
|a RS189
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| 082 |
0 |
4 |
|a 615.1901
|2 23
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| 245 |
0 |
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|a Identification and quantification of drugs, metabolites, drug metabolizing
|h [electronic resource] /
|c edited by Shuguang Ma and Swapan K. Chowdhury.
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| 260 |
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|a Amsterdam :
|b Elsevier,
|c 2020.
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| 300 |
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|a 1 online resource
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| 500 |
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|a Includes index.
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0 |
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|a Intro -- Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters: Concepts, Methods, a ... -- Copyright -- Contents -- Contributors -- Foreword -- References -- Preface -- Part I: Techniques for identifying and quantifying drugs and metabolites -- Chapter 1: Bioanalysis of small and large molecule drugs, metabolites, and biomarkers by LC-MS -- 1. Introduction -- 2. Complexity of contemporary bioanalysis -- 3. Bioanalytical requirements for supporting discovery, nonclinical, and clinical studies -- 4. Current regulatory landscape for bioanalysis
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| 505 |
8 |
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|a 5. General considerations for bioanalysis for sample collection -- 6. Diagnosis and mitigation of nonspecific adsorption loss for urine bioanalysis -- 7. Tissue bioanalysis -- 8. Managing unstable metabolites such as acyl glucuronide -- 9. General considerations for bioanalysis for extraction, chromatography, and MS detection -- 10. Selected applications for LC-MS bioanalysis -- 10.1. LC-MS of large molecules -- 10.1.1. LC-MS bioanalysis of mAb -- 10.1.2. LC-MS bioanalysis of ADC -- 10.1.3. LC-MS bioanalysis of PDC -- 10.1.4. LC-MS bioanalysis of protein biomarkers
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8 |
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|a 10.3.3. Fatty acid amide hydrolase biomarkers (authentic matrix and surrogate analytes) -- 10.4. LC-MS analysis of metabolites and MIST -- 10.4.1. Metabolite quantitation strategy -- 10.4.2. LC-MS bioanalysis of polar metabolites -- 10.4.3. Bioanalysis of chiral compounds -- 10.4.4. Unexpected assay challenge during analysis of patient samples -- 11. Conclusion and future perspective -- References -- Chapter 2: Recent advances in mass spectrometric and other analytical techniques for the identification of drug metabolites -- 1. Introduction -- 2. Sample preparation strategies
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| 505 |
8 |
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|a 2.1. Solid-phase extraction -- 2.2. Supported phase liquid extraction -- 2.3. Liquid-liquid extraction -- 2.4. Protein precipitation -- 3. Optical detectors and chromatographic separation techniques -- 3.1. Ultra-performance liquid chromatography -- 3.2. Supercritical fluid chromatography -- 4. Different types of Ionization techniques and mass spectrometric scan functions -- 4.1. Ionization techniques -- 4.2. Mass analyzers and different acquisition modes -- 4.3. Inductively coupled mass spectrometry (ICP-MS) -- 5. Wet chemistry techniques combined with MS
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| 650 |
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0 |
|a Drugs
|x Analysis.
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| 650 |
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0 |
|a Drugs
|x Metabolism.
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| 650 |
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0 |
|a Metabolites.
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| 650 |
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0 |
|a Biochemical markers.
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| 650 |
1 |
2 |
|a Pharmaceutical Preparations
|x analysis.
|0 (DNLM)D004364Q000032
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| 650 |
1 |
2 |
|a Pharmaceutical Preparations
|x metabolism.
|0 (DNLM)D004364Q000378
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| 650 |
2 |
2 |
|a Biomarkers.
|0 (DNLM)D015415
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| 650 |
|
7 |
|a Biochemical markers.
|2 fast
|0 (OCoLC)fst00831950
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| 650 |
|
7 |
|a Drugs
|x Analysis.
|2 fast
|0 (OCoLC)fst00898769
|
| 650 |
|
7 |
|a Drugs
|x Metabolism.
|2 fast
|0 (OCoLC)fst00898845
|
| 650 |
|
7 |
|a Metabolites.
|2 fast
|0 (OCoLC)fst01017507
|
| 655 |
|
4 |
|a Electronic books.
|
| 655 |
|
0 |
|a Electronic books.
|
| 700 |
1 |
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|a Ma, Shuguang.
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| 700 |
1 |
|
|a Chowdhury, Swapan K.
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| 776 |
0 |
8 |
|c Original
|z 0128200189
|z 9780128200186
|w (OCoLC)1130251159
|
| 856 |
4 |
0 |
|3 ScienceDirect
|u https://www.sciencedirect.com/science/book/9780128200186
|
