Phytochemicals As Lead Compounds for New Drug Discovery
Phytochemicals as Lead Compounds for New Drug Discovery presents complete coverage of the recent advances in the discovery of phytochemicals from medicinal plants as models to the development of new drugs and chemical entities. Functional bioactive compounds of plant origin have been an invaluable s...
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| Other Authors: | , , , , |
| Language: | English |
| Published: |
San Diego :
Elsevier,
2019.
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| Subjects: | |
| Online Access: | ScienceDirect |
| Summary: | Phytochemicals as Lead Compounds for New Drug Discovery presents complete coverage of the recent advances in the discovery of phytochemicals from medicinal plants as models to the development of new drugs and chemical entities. Functional bioactive compounds of plant origin have been an invaluable source for many human therapeutic drugs and have played a major role in the treatment of diseases around the world. These compounds possess enormous structural and chemical diversity and have led to many important discoveries. This book presents fundament concepts and factors affecting the choice for plant-based products, as well as recent advances in computer-aided drug discovery and FDA drug candidacy acceptance criteria. It also details the various bioactive lead compounds and molecular targets for a range of life-threatening diseases including cancer, diabetes, and neurodegenerative diseases. Written by a global team of experts, Phytochemicals as Lead Compounds for New Drug Discovery is an ideal resource for drug developers, phytochemists, plant biochemists, food and medicinal chemists, nutritionists and toxicologists, chemical ecologists, taxonomists, analytical chemists, and other researchers in those fields. It will also be very valuable to professors, students, and researchers in this domain. |
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| Item Description: | 4.1.3.9.2 General toxicity studies |
| Physical Description: | 1 online resource (380 pages) |
| Bibliography: | References2-Factors affecting the choice for plant-based products in drug discoveries; 2.1 Introduction; 2.1.1 The process of drug discovery; 2.1.2 Efficacy of plant material; 2.1.3 Molecular size; 2.1.4 Stability of natural compounds; 2.1.5 Pharmacokinetics and pharmacodynamics; 2.1.6 Factors affecting the collection of plant samples; 2.1.7 Toxicity; 2.1.8 Ease of structural modification; 2.2 Conclusion; References; 3-Advances in computer-aided drug discovery; 3.1 Introduction; 3.1.1 Bioactive compounds as sources of drugs; 3.1.2 Chemical structure determination |
| ISBN: | 0128178914 9780128178911 |