Leucine-Rich Repeat Kinase 2 (LRRK2)
This is the first book to assemble the leading researchers in the field of LRRK2 biology and neurology and provide a snapshot of the current state of knowledge, encompassing all major aspects of its function and dysfunction. The contributors are experts in cell biology and physiology, neurobiology,...
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| Language: | English |
| Published: |
Cham :
Springer International Publishing : Imprint: Springer,
2017.
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| Edition: | 1st ed. 2017. |
| Series: | Advances in Neurobiology,
14 |
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| Online Access: | https://doi.org/10.1007/978-3-319-49969-7 |
Table of Contents:
- Part I: Clinical and Genetic Considerations of LRRK2 Associated Parkinson’s Disease
- Leucine-rich repeat kinase (LRRK2) genetics and Parkinson’s disease
- Clinical features of LRRK2 carriers with Parkinson’s disease
- Part II: Fundamentals of LRRK2 Biology
- LRRK2 phosphorylation
- Understanding the GTPase activity of LRRK2: regulation, function and neurotoxicity
- LRRK2 and autophagy
- Molecular insights and functional implication of LRRK2 dimerization
- LRRK2 and the immune system
- Regulation of LRRK2 by phosphatases
- Part III: LRRK2 Neurodegeneration, Modeling, and Therapeutic Options
- Animal models of LRRK2-associated Parkinson’s disease
- LRRK2 and the “LRRKtosome” at the crossroads of programmed cell death: Clues from RIP kinase relatives
- Interaction of LRRK2 and α-synuclein in Parkinson’s disease
- Mechanisms of mutant LRRK2 neurodegeneration
- Small molecule inhibitors of LRRK2.