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|a 9783319499697
|9 978-3-319-49969-7
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|a 10.1007/978-3-319-49969-7
|2 doi
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|a RC321-580
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|a 612.8
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|a Leucine-Rich Repeat Kinase 2 (LRRK2)
|h [electronic resource] /
|c edited by Hardy J. Rideout.
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| 250 |
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|a 1st ed. 2017.
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|a Cham :
|b Springer International Publishing :
|b Imprint: Springer,
|c 2017.
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|a XVII, 271 p. 27 illus., 17 illus. in color.
|b online resource.
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|a text
|b txt
|2 rdacontent
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|a computer
|b c
|2 rdamedia
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|a online resource
|b cr
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|a text file
|b PDF
|2 rda
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|a Advances in Neurobiology,
|x 2190-5215 ;
|v 14
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|a Part I: Clinical and Genetic Considerations of LRRK2 Associated Parkinson’s Disease -- Leucine-rich repeat kinase (LRRK2) genetics and Parkinson’s disease -- Clinical features of LRRK2 carriers with Parkinson’s disease -- Part II: Fundamentals of LRRK2 Biology -- LRRK2 phosphorylation -- Understanding the GTPase activity of LRRK2: regulation, function and neurotoxicity -- LRRK2 and autophagy -- Molecular insights and functional implication of LRRK2 dimerization -- LRRK2 and the immune system -- Regulation of LRRK2 by phosphatases -- Part III: LRRK2 Neurodegeneration, Modeling, and Therapeutic Options -- Animal models of LRRK2-associated Parkinson’s disease -- LRRK2 and the “LRRKtosome” at the crossroads of programmed cell death: Clues from RIP kinase relatives -- Interaction of LRRK2 and α-synuclein in Parkinson’s disease -- Mechanisms of mutant LRRK2 neurodegeneration -- Small molecule inhibitors of LRRK2.
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|a This is the first book to assemble the leading researchers in the field of LRRK2 biology and neurology and provide a snapshot of the current state of knowledge, encompassing all major aspects of its function and dysfunction. The contributors are experts in cell biology and physiology, neurobiology, and medicinal chemistry, bringing a multidisciplinary perspective on the gene and its role in disease. The book covers the identification of LRRK2 as a major contributor to the pathogenesis of Parkinson's Disease. It also discusses the current state of the field after a decade of research, putative normal physiological roles of LRRK2, and the various pathways that have been identified in the search for the mechanism(s) of its induction of neurodegeneration.
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|a Neurosciences.
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|a Neurology .
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|a Neurosciences.
|0 https://scigraph.springernature.com/ontologies/product-market-codes/B18006
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|a Neurology.
|0 https://scigraph.springernature.com/ontologies/product-market-codes/H36001
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|a Rideout, Hardy J.
|e editor.
|4 edt
|4 http://id.loc.gov/vocabulary/relators/edt
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|a SpringerLink (Online service)
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|t Springer Nature eBook
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|i Printed edition:
|z 9783319499673
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| 776 |
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|i Printed edition:
|z 9783319499680
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| 776 |
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|i Printed edition:
|z 9783319842875
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|a Advances in Neurobiology,
|x 2190-5215 ;
|v 14
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4 |
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|u https://doi.org/10.1007/978-3-319-49969-7
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|a ZDB-2-SBL
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|a ZDB-2-SXB
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|a Biomedical and Life Sciences (SpringerNature-11642)
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| 950 |
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|a Biomedical and Life Sciences (R0) (SpringerNature-43708)
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