Fibroblast growth factors /
Fibroblast Growth Factors presents research and results from the leading global research group on FGF, providing up-to-date and comprehensive coverage of the field. The book describes the history, basic research and growth engineering technology involved with FGFs, while also introducing detailed re...
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| Language: | English |
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London : Beijing L
Academic Press ; Higher Education Press,
[2018]
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| Online Access: | ScienceDirect |
Table of Contents:
- Front Cover; Fibroblast Growth Factors; Fibroblast Growth Factors; Copyright; Contents; Preface; Preface; 1
- Engineered Growth Factor; Engineered Growth Factors and Cutaneous WoundHealing: Success and Possible Questions in thePast 10 Years; 1. Introduction; 2. Is There a Need for Exogenous Application of Growth Factors in Acute or Chronic Wounds?; 3. Have Growth Factors Altered Clinical Practice in the Past and Will They Alter It in the Future?; 4. Do We Need a Special Delivery System for the Growth Factors in Local Wound Healing?
- 5. Is It Safe to Use Growth Factors to Promote Wound Healing?6. Have All Problems Involved in Wound Healing Been Solved With Growth Factor Application?; 7. Can Perfect Wound Healing Be Achieved in Wounds Treated With Growth Factors?; 8. How Great a Change in Healing Events Would Require a Growth Factor to Become Clinically Important?; 9. What Needs to Be Done to Include Growth Factors in Clinical Practice Within the Next 5-10Years?; References; 2
- FGFs in Injury Repair and Regeneration
- Regulation of Autophagy and Ubiquitinated ProteinAccumulation by bFGF Promotes FunctionalRecovery and Neural Protection in a Rat Model ofSpinal Cord Injury1. Introduction; 2. Materials and Methods; 2.1 Reagents and Antibodies; 2.2 Cell Culture; 2.3 Procedure for Investigating an Animal Model of Spinal Cord Injury; 2.4 Locomotion Recovery Assessment; 2.5 Hematoxylin-Eosin Staining and Nissl Staining; 2.6 Western Blot Analysis; 2.7 Immunofluorescence Staining; 2.8 Statistical Analysis; 3. Results; 3.1 bFGF Decreases Motor Neuron Loss and Improves Functional Recovery of SCI In Vivo
- 3.2 The Protective Effect of bFGF Is Related to Inhibited Autophagy in the SCI Model Mice3.3 Activation of PI3K/Akt/mTOR Signaling Pathways Is Involved in the Role of bFGF in SCI Recovery; 3.4 bFGF Improves Recovery After SCI by Autophagic Clearance of Ubiquitinated Protein Accumulation; 3.5 Combination With the Autophagy Sensitizer Rapamycin Partially Abolishes the Protective Effect of bFGF in SCI Model Rats; 3.6 Exogenous bFGF Protects PC-12 Cells by Inhibition of Excessive Autophagy In Vitro; 4. Discussion; The Antiscar Effects of bFGF on Wound RepairIn Vitro and In Vivo; 1. Introduction
- 2. Materials and Methods2.1 Ethics Statement; 2.2 Animal Model; 2.3 Histological Examination and Immunohistochemistry Staining; 2.4 Terminal Deoxynucleotidyl Transferase-Mediated dUTP Nick-End Labeling Staining; 2.5 Collagen I and Collagen III Quantification; 2.6 Western Blot; 2.7 Fibroblasts Culture; 2.8 Quantitative Real-Time PCR; 2.9 Statistical Analysis; 3. Results; 3.1 bFGF Accelerates Acute Wound Closure in the Rat-Incised Injury Model; 3.2 bFGF Alleviates the Scar Formation in the Rabbit Ear Model; 3.3 Effect of bFGF on Collagen I and Collagen III Synthesis