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Group-Sequential Clinical Trials with Multiple Co-Objectives

This book focuses on group sequential methods for clinical trials with co-primary endpoints based on the decision-making frameworks for: (1) rejecting the null hypothesis (stopping for efficacy), (2) rejecting the alternative hypothesis (stopping for futility), and (3) rejecting the null or alternat...

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Main Authors: Hamasaki, Toshimitsu. (Author, http://id.loc.gov/vocabulary/relators/aut), Asakura, Koko. (http://id.loc.gov/vocabulary/relators/aut), Evans, Scott R. (http://id.loc.gov/vocabulary/relators/aut), Ochiai, Toshimitsu. (http://id.loc.gov/vocabulary/relators/aut)
Corporate Author: SpringerLink (Online service)
Language:English
Published: Tokyo : Springer Japan : Imprint: Springer, 2016.
Edition:1st ed. 2016.
Series:JSS Research Series in Statistics,
Subjects:
Statistics .
Statistical Theory and Methods.
Statistics for Life Sciences, Medicine, Health Sciences.
Statistics for Social Sciences, Humanities, Law.
Online Access:https://doi.org/10.1007/978-4-431-55900-9
Table of Contents:
  • 1. Introduction
  • 2. Early Stopping for Efficacy in Clinical Trials with multiple co-primary endpoints
  • 3. Sample size recalculation based on observed effects at interim
  • 4. Early stopping for futility in Clinical Trials with multiple co-primary endpoints
  • 5. Early stopping for futility or Efficacy in Clinical Trials with multiple co-primary endpoints
  • 6. Clinical Trials with multiple primary endpoints
  • 7. Group-sequential designs for three-arm noninferiority clinical trials
  • 8. Further development: topics not covered in this book.

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