Filaggrin Basic Science, Epidemiology, Clinical Aspects and Management /

Filaggrin proteins are expressed in several human tissues, including the skin, oral mucosa, conjunctivae, esophagus, cervix, and testes.  While filaggrin guarantees both structural and functional normality of the human epidermis, its role in other tissues is largely unknown. Epidermal deficiency of...

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Corporate Author: SpringerLink (Online service)
Other Authors: Thyssen, Jacob P. (Editor, http://id.loc.gov/vocabulary/relators/edt), Maibach, Howard I. (Editor, http://id.loc.gov/vocabulary/relators/edt)
Language:English
Published: Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 2014.
Edition:1st ed. 2014.
Subjects:
Online Access:https://doi.org/10.1007/978-3-642-54379-1
Table of Contents:
  • BASIC SCIENCE: Mutations in the Filaggrin Gene
  • Morphology of Normal and Filaggrin Depleted Epidermis
  • Function of Filaggrin and Its Metabolites
  • Influence On Skin Lipids
  • Inflammatory Driven Depletion of Filaggrin Proteins
  • Animal Models
  • In Vitro Models
  • EPIDEMIOLOGY: Prevalence Rates In Different Races
  • Gene-Environment Interactions
  • Heterozygous Advantage
  • FILAGGRIN AND SKIN DISEASE: Ichthyosis Vulgaris and Other Disorders of Cornification
  • Atopic Dermatitis
  • Allergic Contact Dermatitis
  • Irritant Contact Dermatitis
  • Hand Eczema
  • Psoriasis
  • Disorders In The Seborrheic Areas
  • Infections
  • Cancer and Tumors
  • Autoimmune and Connective Tissue Disorders
  • Pigmentation Disorders
  • Sweat Gland Disorders
  • Nails and Hair
  • FILAGGRIN AND NON-CUTANEOUS DISEASE: Asthma
  • Rhinitis
  • Food Allergy
  • Diabetes
  • Cardiac Disease
  • Inflammatory Bowel Disease
  • Ophthalmic Disease
  • Rheumatoid Arthritis
  • Cancer
  • Vitamin D
  • MANAGEMENT.