Distribution and Phenotype of Proliferating Cells in the Forebrain of Adult Macaque Monkeys after Transient Global Cerebral Ischemia
| Main Authors: | , , |
|---|---|
| Corporate Author: | |
| Language: | English |
| Published: |
Berlin, Heidelberg :
Springer Berlin Heidelberg : Imprint: Springer,
2007.
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| Edition: | 1st ed. 2007. |
| Series: | Advances in Anatomy, Embryology and Cell Biology,
191 |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/978-3-540-39617-8 |
Table of Contents:
- 1 Introduction.-.1 Studies on cell proliferation in adult primate brain
- 1.2 Methodological considerations in detecting cell proliferation
- 1.3 Cell proliferation in rodent brain after ischemia
- 1.4 Global cerebral ischemia in primates
- 2 Materials and Methods
- 2.1 Animal subjects
- 2.2 Bromodeoxyuridine infusion protocol
- 2.3 Tissue processing
- 2.4 Immunohistochemistry
- 2.5 Detection of DNA damage and degenerating cells
- 2.6 Electron microscopy
- 2.7 Image acquisition and analysis
- 2.8 Statistical analysis
- 3 Results
- 3.1 Hippocampal formation
- 3.1.1 Dentate gyrus
- 3.1.2 Cornu Ammonis
- 3.1.3 Subiculum
- 3.2 Subventricular zone of the inferior horn of the lateral ventricle (SVZi)
- 3.3 Temporal lobe
- 3.3.1 Parahippocampal region
- 3.3.2 Temporal neocortex
- 3.4 Subventricular zone of the anterior horn of the lateral ventricle (SVZa)
- 3.5 Rostral migratory stream and olfactory bulb
- 3.6 Frontal neocortex and striatum
- 4 Discussion
- 4.1 BrdU as a proliferation marker
- 4.2 Effects of ischemia on cell proliferation and differentiation
- 4.3 Sustained progenitor cell existence in germinative zones
- 4.4 Implications of monkey findings for therapies in humans
- 5 Summary
- References
- Subject Index.