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Human Neural Stem Cells From Generation to Differentiation and Application /

This book summarizes early pioneering achievements in the field of human neural stem cell (hNSC) research and combines them with the latest advances in stem cell technology, including reprogramming and gene editing. The powerful potential of hNSC to generate and repair the developing and adult CNS h...

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Corporate Author: SpringerLink (Online service)
Other Authors: Buzanska, Leonora. (Editor, http://id.loc.gov/vocabulary/relators/edt)
Language:English
Published: Cham : Springer International Publishing : Imprint: Springer, 2018.
Edition:1st ed. 2018.
Series:Results and Problems in Cell Differentiation, 66
Subjects:
Stem cells.
Medical genetics.
Neurosciences.
Gene therapy.
Cytogenetics.
Stem Cells.
Gene Function.
Gene Therapy.
Online Access:https://doi.org/10.1007/978-3-319-93485-3
Table of Contents:
  • Part 1. Derivation and/or generation of human neural stem cells
  • 1. Derivation of neural stem cells from the developing and adult human brain
  • 2. Comparison of after-birth and adult somatic tissues in ability to generate human neural stem cells
  • 3. Neural stem cells derived from human induced pluripotent stem cells and their use in models of CNS injury
  • 4. Generation of human neural stem cells by direct phenotypic conversion
  • Part 2. Differentiation and underlying mechanisms
  • 5. Epigenetic regulation of human neural stem cell differentiation
  • 6. Human iPSC-derived neuronal committed cells reveal common developmental genome deprograming in schizophrenia
  • 7. Genome editing in human neural stem and progenitor cells
  • 8. Brain Organoids – expanding our understanding of human development and disease
  • 9. Microenvironmental cues in human neural stem cell fate commitment
  • Part 3. Therapeutic potential of human neural stem cells
  • 10. Updates on Human Neural Stem Cells: From Generation, Maintenance and Differentiation to Research and Translational Applications
  • 11. Human neural stem cells for ischemic stroke treatment
  • 12. Modeling pediatric and neuropsychiatric diseases using human iPSC
  • 13. Neural stem cell dysfunction in human brain diseases
  • 14. Human Fetal Neural Stem Cells for neurodegenerative disease treatment.

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