Carbohydrate-Based Interactions at the Molecular and the Cellular Level

This book offers a clearly written and highly accessible account of two different aspects of carbohydrate chemistry. Carbohydrates are an essential component of life and have many important biological functions, but the details of how carbohydrates interact with other biomolecules to mediate biologi...

Full description

Main Author: Hudson, Kieran L. (Author, http://id.loc.gov/vocabulary/relators/aut)
Corporate Author: SpringerLink (Online service)
Language:English
Published: Cham : Springer International Publishing : Imprint: Springer, 2018.
Edition:1st ed. 2018.
Series:Springer Theses, Recognizing Outstanding Ph.D. Research,
Subjects:
Online Access:https://doi.org/10.1007/978-3-319-77706-1
LEADER 04139nam a22006015i 4500
001 978-3-319-77706-1
003 DE-He213
005 20210619112624.0
007 cr nn 008mamaa
008 180528s2018 gw | s |||| 0|eng d
020 |a 9783319777061  |9 978-3-319-77706-1 
024 7 |a 10.1007/978-3-319-77706-1  |2 doi 
050 4 |a QD320-327 
072 7 |a PSBF  |2 bicssc 
072 7 |a SCI013040  |2 bisacsh 
072 7 |a PSB  |2 thema 
082 0 4 |a 547.78  |2 23 
100 1 |a Hudson, Kieran L.  |e author.  |4 aut  |4 http://id.loc.gov/vocabulary/relators/aut 
245 1 0 |a Carbohydrate-Based Interactions at the Molecular and the Cellular Level  |h [electronic resource] /  |c by Kieran L. Hudson. 
250 |a 1st ed. 2018. 
264 1 |a Cham :  |b Springer International Publishing :  |b Imprint: Springer,  |c 2018. 
300 |a XXIX, 198 p. 98 illus., 49 illus. in color.  |b online resource. 
336 |a text  |b txt  |2 rdacontent 
337 |a computer  |b c  |2 rdamedia 
338 |a online resource  |b cr  |2 rdacarrier 
347 |a text file  |b PDF  |2 rda 
490 1 |a Springer Theses, Recognizing Outstanding Ph.D. Research,  |x 2190-5053 
505 0 |a Introduction -- Protein-Carbohydrate Interactions in Protein X-ray Crystal Structures -- The Nature of Protein-Carbohydrate Interactions -- The Modifiable Scaffold for Tissue Engineering -- Carbohydrate Modifiers for Tissue Engineering Scaffolds -- Conclusions and Future Directions -- Experimental Details and Supplementary Data. 
520 |a This book offers a clearly written and highly accessible account of two different aspects of carbohydrate chemistry. Carbohydrates are an essential component of life and have many important biological functions, but the details of how carbohydrates interact with other biomolecules to mediate biological signalling remain unclear. Firstly, this thesis details innovative methods to mine protein structural data to uncover new features of carbohydrate-based interactions. It also explains these findings using physical chemistry, specifically CH–pi interactions associated with the properties of the interacting partners. Carbohydrates are also critical for tissue growth and development, yet are underexploited in the materials science that underpins much of regenerative medicine. As such, the second part of this thesis describes a diverse array of techniques ranging from synthetic chemistry and enzymatic synthesis to prepare a wide variety of carbohydrates, and materials chemistry to prepare glycosylated hydrogels, to cell biology to determine the effects on cellular development for tissue engineering applications. 
650 0 |a Carbohydrates. 
650 0 |a Proteins . 
650 0 |a Chemistry, Physical and theoretical. 
650 0 |a Regenerative medicine. 
650 0 |a Tissue engineering. 
650 0 |a Physical chemistry. 
650 0 |a Analytical chemistry. 
650 1 4 |a Carbohydrate Chemistry.  |0 https://scigraph.springernature.com/ontologies/product-market-codes/C19030 
650 2 4 |a Protein-Ligand Interactions.  |0 https://scigraph.springernature.com/ontologies/product-market-codes/L14060 
650 2 4 |a Theoretical and Computational Chemistry.  |0 https://scigraph.springernature.com/ontologies/product-market-codes/C25007 
650 2 4 |a Regenerative Medicine/Tissue Engineering.  |0 https://scigraph.springernature.com/ontologies/product-market-codes/L16080 
650 2 4 |a Physical Chemistry.  |0 https://scigraph.springernature.com/ontologies/product-market-codes/C21001 
650 2 4 |a Analytical Chemistry.  |0 https://scigraph.springernature.com/ontologies/product-market-codes/C11006 
710 2 |a SpringerLink (Online service) 
773 0 |t Springer Nature eBook 
776 0 8 |i Printed edition:  |z 9783319777054 
776 0 8 |i Printed edition:  |z 9783319777078 
776 0 8 |i Printed edition:  |z 9783030085179 
830 0 |a Springer Theses, Recognizing Outstanding Ph.D. Research,  |x 2190-5053 
856 4 0 |u https://doi.org/10.1007/978-3-319-77706-1 
912 |a ZDB-2-CMS 
912 |a ZDB-2-SXC 
950 |a Chemistry and Materials Science (SpringerNature-11644) 
950 |a Chemistry and Material Science (R0) (SpringerNature-43709)