Emerging Concepts Targeting Immune Checkpoints in Cancer and Autoimmunity
This volume reviews the current state of research on immune checkpoints and offers novel concepts. It discusses the two most important immune checkpoints: T lymphocyte-associated antigen-4 (CTLA-4) and programmed cell death-1 (PD-1). It shows that antagonistic antibodies against these two molecules...
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| Language: | English |
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Cham :
Springer International Publishing : Imprint: Springer,
2017.
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| Edition: | 1st ed. 2017. |
| Series: | Current Topics in Microbiology and Immunology,
410 |
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| Online Access: | https://doi.org/10.1007/978-3-319-68929-6 |
Table of Contents:
- Regulatory T cells: molecular and cellular basis for immunoregulation
- Overview of LAG-3- expressing, IL-10-producing regulatory T cells
- Regulatory Dendritic Cells
- Role of PD-1 in immunity and diseases
- CTLA-4, an essential immune-checkpoint for T cell activation
- Tim-3, Lag-3, and TIGIT
- SOCS1: regulator of T cells in autoimmunity and cancer
- Mining the complex family of protein tyrosine phosphatases for checkpoint regulators in immunity
- Immune regulation by ubiquitin tagging as checkpoint code
- MicroRNA in Immune Regulation.