Decoding the Antibody Repertoire High Throughput Sequencing of Multiple Transcripts from Single B Cells /
This thesis outlines the development of the very first technology for high-throughput analysis of paired heavy and light-chain antibody sequences, opening the door for the discovery of new antibodies and the investigation of adaptive immune responses to vaccines and diseases. By designing two new te...
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| Language: | English |
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Cham :
Springer International Publishing : Imprint: Springer,
2017.
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| Edition: | 1st ed. 2017. |
| Series: | Springer Theses, Recognizing Outstanding Ph.D. Research,
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| Online Access: | https://doi.org/10.1007/978-3-319-58518-5 |
Table of Contents:
- Background
- High-throughput Sequencing of the Paired Human Immunoglobulin Heavy and Light Chain Repertoire
- In-Depth Determination and Analysis of the Human Paired Heavy and Light Chain Antibody Repertoire
- Paired VH:VL Analysis of Naïve B Cell Repertoires and Comparison to Antigen-Experienced B Cell Repertoires in Healthy Human Donors
- Conclusions and Future Perspectives
- Appendices.