Leptin Regulation and Clinical Applications /
Twenty years after its discovery, recombinant human leptin has been approved by the Food and Drug Administration for the treatment of patients with lipodystrophy. Beginning with a synthesis of the vast body of work on its discovery, dissection of mechanisms, and effects in experimental models , the...
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| Language: | English |
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Cham :
Springer International Publishing : Imprint: Springer,
2015.
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| Edition: | 1st ed. 2015. |
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| Online Access: | https://doi.org/10.1007/978-3-319-09915-6 |
Table of Contents:
- Discovery of leptin and elucidation of leptin gene expression
- Leptin receptors and mechanism of action
- Leptin interaction with brain orexigenic and anorexigenic pathways
- Measurement of circulating leptin and soluble leptin receptors
- Physiological and hormonal factors that influence leptin production
- Leptin, obesity and leptin resistance
- Leptin and intermediary metabolism: Focus on glucoregulation and lipid metabolism
- Leptin in acute stress
- Leptin and the kidney
- Leptin, immune function, and inflammation
- Leptin and bone
- Leptin, cell cycle, and cancer
- Leptin, the autonomic nervous system, and hypertension
- Dynamic leptin secretion in obesity and diabetes
- Leptin therapy of congenital leptin deficiency
- Leptin therapy in people with normal leptin gene
- Leptin therapy in patients with lipodystrophy and syndromic insulin resistance
- Leptin therapy in women with hypothalamic amenorrhea
- Leptin therapy as a substitute for insulin replacement in experimental models of diabetes: Clinical implications in humans
- Novel combinatorial therapies involving leptin: Opportunities for mechanistic advances and therapeutic translation in human diseases.