Abeta Peptide and Alzheimer's Disease Celebrating a Century of Research /

Abeta Peptide and Alzheimer’s Disease summarizes current knowledge of beta-amyloid peptide (Aß) and its role as the major culprit in Alzheimer’s Disease (AD), shown by recent advances in genetics and brain biochemistry. Written by leaders in the industrial and academic world specializing in this rap...

Full description

Corporate Author: SpringerLink (Online service)
Other Authors: Barrow, Colin J. (Editor, http://id.loc.gov/vocabulary/relators/edt), Small, David H. (Editor, http://id.loc.gov/vocabulary/relators/edt)
Language:English
Published: London : Springer London : Imprint: Springer, 2007.
Edition:1st ed. 2007.
Subjects:
Online Access:https://doi.org/10.1007/978-1-84628-440-3
LEADER 04411nam a22005775i 4500
001 978-1-84628-440-3
003 DE-He213
005 20210616065929.0
007 cr nn 008mamaa
008 100301s2007 xxk| s |||| 0|eng d
020 |a 9781846284403  |9 978-1-84628-440-3 
024 7 |a 10.1007/978-1-84628-440-3  |2 doi 
050 4 |a RC346-429.2 
072 7 |a MJN  |2 bicssc 
072 7 |a MED056000  |2 bisacsh 
072 7 |a MKJ  |2 thema 
082 0 4 |a 616.8  |2 23 
245 1 0 |a Abeta Peptide and Alzheimer's Disease  |h [electronic resource] :  |b Celebrating a Century of Research /  |c edited by Colin J. Barrow, David H. Small. 
250 |a 1st ed. 2007. 
264 1 |a London :  |b Springer London :  |b Imprint: Springer,  |c 2007. 
300 |a XI, 298 p.  |b online resource. 
336 |a text  |b txt  |2 rdacontent 
337 |a computer  |b c  |2 rdamedia 
338 |a online resource  |b cr  |2 rdacarrier 
347 |a text file  |b PDF  |2 rda 
505 0 |a A Brief Introduction to the History of the ?-Amyloid Protein (A?) of Alzheimer’s Disease -- The A?centric Pathway of Alzheimer’s Disease -- The Function of the Amyloid Precursor Protein Family -- The Involvement of A? in the Neuroinflammatory Response -- Amyloid ?-Peptide(1-42), Oxidative Stress, and Alzheimer’s Disease -- Amyloid Toxicity, Synaptic Dysfunction, and the Biochemistry of Neurodegeneration in Alzheimer’s Disease -- A? Variants and Their Impact on Amyloid Formation and Alzheimer’s Disease Progression -- Copper Coordination by ?-Amyloid and the Neuropathology of Alzheimer’s Disease -- Cholesterol and Alzheimer’s Disease -- Amyloid ?-Peptide and Central Cholinergic Neurons: Involvement in Normal Brain Function and Alzheimer’s Disease Pathology -- Physiologic and Neurotoxic Properties of A? Peptides -- Impact of ?-Amyloid on the Tau Pathology in Tau Transgenic Mouse and Tissue Culture Models -- Glial Cells and A? Peptides in Alzheimer’s Disease Pathogenesis -- The Role of Presenilins in A?-Induced Cell Death in Alzheimer’s Disease -- Immunotherapeutic Approaches to Alzheimer’s Disease -- Mouse Models of Alzheimer’s Disease. 
520 |a Abeta Peptide and Alzheimer’s Disease summarizes current knowledge of beta-amyloid peptide (Aß) and its role as the major culprit in Alzheimer’s Disease (AD), shown by recent advances in genetics and brain biochemistry. Written by leaders in the industrial and academic world specializing in this rapidly moving area, the book covers fundamental biochemical studies on the Aß peptide, the genetic impact on Aß expression and processing, and various AD therapeutic strategies that target Aß. Although specifically focusing on Aß and AD, there is also some discussion on the similarity and differences of this peptide and AD with other amyloidogenic diseases, such as prion disease, Parkinson’s and Huntington’s. This book will primarily be of interest to AD researchers and clinicians but also to researchers of other amyloid diseases. 
650 0 |a Neurology . 
650 0 |a Neurosurgery. 
650 0 |a Medical biochemistry. 
650 0 |a Neurosciences. 
650 0 |a Molecular biology. 
650 0 |a Human genetics. 
650 1 4 |a Neurology.  |0 https://scigraph.springernature.com/ontologies/product-market-codes/H36001 
650 2 4 |a Neurosurgery.  |0 https://scigraph.springernature.com/ontologies/product-market-codes/H39000 
650 2 4 |a Medical Biochemistry.  |0 https://scigraph.springernature.com/ontologies/product-market-codes/H35005 
650 2 4 |a Neurosciences.  |0 https://scigraph.springernature.com/ontologies/product-market-codes/B18006 
650 2 4 |a Molecular Medicine.  |0 https://scigraph.springernature.com/ontologies/product-market-codes/B1700X 
650 2 4 |a Human Genetics.  |0 https://scigraph.springernature.com/ontologies/product-market-codes/B12008 
700 1 |a Barrow, Colin J.  |e editor.  |4 edt  |4 http://id.loc.gov/vocabulary/relators/edt 
700 1 |a Small, David H.  |e editor.  |4 edt  |4 http://id.loc.gov/vocabulary/relators/edt 
710 2 |a SpringerLink (Online service) 
773 0 |t Springer Nature eBook 
776 0 8 |i Printed edition:  |z 9781848008649 
776 0 8 |i Printed edition:  |z 9781852339616 
776 0 8 |i Printed edition:  |z 9781447162346 
856 4 0 |u https://doi.org/10.1007/978-1-84628-440-3 
912 |a ZDB-2-SME 
912 |a ZDB-2-SXM 
950 |a Medicine (SpringerNature-11650) 
950 |a Medicine (R0) (SpringerNature-43714)