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Innate Tolerance in the CNS Translational Neuroprotection by Pre- and Post-Conditioning /

Cerebral ischemia from cardiac arrest, stroke, and subarachnoid and intracerebral hemorrhage, together with trauma, epilepsy, and other CNS pathologies, continue to impose immense burdens of morbidity and mortality the world over. Despite many decades of research aimed at understanding the genetic a...

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Corporate Author: SpringerLink (Online service)
Other Authors: Gidday, Jeffrey M. (Editor, http://id.loc.gov/vocabulary/relators/edt), Perez-Pinzon, Miguel A. (Editor, http://id.loc.gov/vocabulary/relators/edt), Zhang, John H. (Editor, http://id.loc.gov/vocabulary/relators/edt)
Language:English
Published: New York, NY : Springer New York : Imprint: Springer, 2013.
Edition:1st ed. 2013.
Series:Springer Series in Translational Stroke Research,
Subjects:
Neurosciences.
Neurology .
Neurobiology.
Neurology.
Online Access:https://doi.org/10.1007/978-1-4419-9695-4
Table of Contents:
  • Preface
  • Section I.   Comparative Physiology and Historical Background
  • 1. Tolerance, Historical Review
  • 2. Anoxia resistance in lower and higher vertebrates
  • 3. Hibernation:  A Natural Model of Tolerance to Cerebral Ischemia/Reperfusion
  • 4. Preconditioning in the Heart
  • Section II.   Conditioning Methods
  • 5. Neuroprotection and Physical Preconditioning:  Exercise, Hypothermia, and Hyperthermia
  • 6. A New Future in Brain Preconditioning Based on Nutraceuticals:  Focus on α-Linolenic Omega-3 Fatty Acids for Stroke Protection
  • 7. Medical Gases for Conditioning:  Volatile Anesthetics, Hyperbaric Oxygen, and Hydrogen Sulfide
  • 8. Hypoxic Preconditioning in the CNS
  • 9. Pharmacologic Preconditioning
  • 10. Surgical Methods to Induce Brain Preconditioning
  • Section III. Conditioning Models for Cerebral Ischemia
  • 11. Tolerance Against Global Cerebral Ischemia:  Experimental Strategies, Mechanisms, and Clinical Applications
  • 12. Preconditioning and Neuroprotection in the Immature Brain
  • 13. Conditioning Studies in Focal Cerebral Ischemia:  Model Selection, Physiological Monitoring, and Other Methodological Issues
  • 14. Preconditioning for Subarachnoid Hemorrhage
  • 15. Preconditioning for Intracerebral Hemorrhage
  • 16. The Protective Effects of Ischemic Postconditioning in Experimental Stroke
  • Section IV. Mechanisms of Preconditioning
  • 17. Synaptic Signaling in Ischemic Tolerance
  • 18
  • The Genomics of Preconditioning and Ischemic Tolerance
  • 19. How do Subcellular Organelles Participate in Preconditioning-Conferred Neuroprotection?
  • 20. Ischemic Preconditioning–Mediated Signaling Pathways Lead to Tolerance Against Cerebral Ischemia
  • 21. Preconditioning the Neurovascular Unit:  Tolerance in the Brain’s Non-Neuronal Cells
  • Section V.   Other Neurological Disorders
  • 22. Preconditioning for Surgical Brain Injury
  • 23. Intrinsic Neuroprotection in Traumatic Brain Injury
  • 24. Preconditioning for Epilepsy
  • 25. Ischemic Pre- and Post-Conditioning in the Retina
  • Section VI. Clinical Applications
  • 26. Clinical Cerebral Ischemic Preconditioning
  • 27. Preconditioning Strategy:  Coronary Bypass, Subarachnoid Hemorrhage, Temporary Proximal Vessel Occlusion in Carotid Revascularization, and Intracranial Aneurysm Surgery
  • 28. HBO preconditioning for TBI and Stroke Patients
  • 29. Electroacupuncture Preconditioning for Stroke Patients
  • 30. Clinical Trials of Ischemic Conditioning
  • Epilogue
  • Index.    .

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