03167cam a2200505Ii 4500 on1076873257 OCoLC 20210423014334.0 m o d cr cnu|||unuuu 181203s2019 ne ob 001 0 eng d N$T eng rda pn N$T N$T YDX OPELS OCLCQ N$T S2H OCLCO 1077946767 9780081026625 (electronic bk.) 0081026625 (electronic bk.) 9780081026618 (electronic bk.) 0081026617 (electronic bk.) (OCoLC)1076873257 (OCoLC)1077946767 QP552.E59 MED 075000 bisacsh SCI 036000 bisacsh 612.791 23 Patel, Harun M., author. Third-Generation EGFR Inhibitors : Overcoming EGFR Resistance and Toxicity Problems / Harun M. Patel, Rahul Pawara, Sanjay J. Surana. Third-generation epidermal growth factor receptor inhibitors First edition. Amsterdam : Elsevier, [2019] 1 online resource text txt rdacontent computer c rdamedia online resource cr rdacarrier Includes bibliographical references and index. Online resource; title from PDF title page (EBSCO, viewed December 5, 2018). Third Generation EGFR Inhibitors: Overcoming EGFR Resistance and Toxicity Problems reviews current issues relating to the design of reversible and irreversible third generation EGFR inhibitors, highlighting the types of mutation responsible for resistance, and providing different chemical starting points for researchers to optimize and develop in designing the next generation of drugs. Beginning with an introduction to EGFR inhibitors and a review of inhibitors currently approved or in clinical trials, the book goes on to discuss current approaches in the development of both covalent irreversible and covalent reversible EGFR Inhibitors. In addition, mechanisms of resistance to third generation inhibitors, and discovery of fourth generation allosteric C797S inhibitors are explored before a discussion of potential future trends. This comprehensive coverage of the design and development of improved analogues to overcome the problems of resistance and toxicity associated with third generation EGFR inhibitors makes Third Generation EGFR Inhibitors a crucial resource for medicinal chemists, drug developers, and researchers investigating cancer therapeutics. Epidermal growth factor Receptors Testing. Epidermal growth factor Receptors Inhibitors. Protein-tyrosine kinase Inhibitors Therapeutic use. MEDICAL Physiology. bisacsh SCIENCE Life Sciences Human Anatomy & Physiology. bisacsh Electronic books. Electronic books. Pawara, Rahul, author. Surana, Sanjay J., author. Print version: 0081026617 9780081026618 (OCoLC)1047783607 ScienceDirect https://www.sciencedirect.com/science/book/9780081026618