06717cam a2200757Ii 4500 on1035844945 OCoLC 20210423014326.0 m o d cr cnu|||unuuu 180517t20182018enk ob 001 0 eng d 2017961660 N$T eng rda pn N$T N$T OPELS YDX EBLCP D6H OCLCF CASUM UAB OTZ NLE INT MERER DKU UKMGB OCLCQ U3W OCLCO OCLCQ OCLCA LVT OCLCA TKN OCLCO DEBBG OCLCQ SNK OCLCQ CQ$ OCLCQ OCLCO S2H OCLCO VT2 OCLCA 018873091 Uk 101732748 DNLM 1036761421 1041923720 1059370055 1235831394 9780128033708 (electronic bk.) 0128033703 (electronic bk.) 9780128033692 012803369X (OCoLC)1035844945 (OCoLC)1036761421 (OCoLC)1041923720 (OCoLC)1059370055 (OCoLC)1235831394 QR181 2018 G-582 QW 504 HEA 039000 bisacsh MED 014000 bisacsh MED 022000 bisacsh MED 112000 bisacsh MED 045000 bisacsh 616.079 23 Structural biology in immunology : structure/function of novel molecules of immunologic importance / edited by Chaim Putterman, David Cowburn, Steven Almo. London, United Kingdom : Academic Press, an imprint of Elsevier, [2018] Ã2018 1 online resource text txt rdacontent computer c rdamedia online resource cr rdacarrier Online resource; title from PDF title page (EBSCO, viewed May 21, 2018). Structural Biology in Immunology, Structure/Function of Novel Molecules of Immunologic Importance delivers important information on the structure and functional relationships in novel molecules of immunologic interest. Due to an increasingly sophisticated understanding of the immune system, the approach to the treatment of many immune-mediated diseases, including multiple sclerosis, systemic lupus erythematosus, rheumatoid arthritis, and inflammatory bowel disease has been dramatically altered. Furthermore, there is an increasing awareness of the critical role of the immune system in cancer biology. The improved central structure function relationships presented in this book will further enhance our ability to understand what defects in normal individuals can lead to disease. Front Cover; Structural Biology in Immunology: Structure/Function of Novel Molecules of Immunologic Importance; Copyright; Contents; Contributors; Chapter 1: Organization of Immunological Synapses and Kinapses; 1.1 Introduction; 1.2 Receptors and Ligands of the Immunological Synapse and Kinapse; 1.2.1 T-cell Receptor and pAgMHC; 1.2.2 Adhesion Molecules; 1.2.3 Costimulatory and Checkpoint Receptors; 1.2.4 Nectins and Other Adhesion Receptors; 1.2.5 Coreceptors and Large Transmembrane Phosphatases; 1.3 Phase-Like Behavior and Phase Separation in Signaling. 1.3.1 Phase Separation in Adhesion Plane of Cell-Cell Interfaces1.3.2 Phase-Separated Lipid Domains in Plasma Membrane; 1.3.3 Phase Separation in Membrane Proximal Signaling; 1.3.4 Cytoskeletal Networks; 1.4 Microvilli/Filopodia; 1.4.1 Rosette-Shaped Actin Network; 1.5 Synaptic Cleft Formation; 1.5.1 Membrane Traffic to Maintain Signaling; 1.5.2 Extracellular Vesicles to Terminate Signaling and Relay Messages; 1.5.3 Directed Release of Effector Molecules Through Exocytosis; 1.6 Conclusions; Acknowledgments; References. Chapter 2: Principles of Protein Recognition by Small T-Cell Adhesion Proteins and Costimulatory Receptors2.1 Introduction; 2.2 Cell-Cell Recognition and Adhesion: CD2 Family Proteins; 2.2.1 Rat sCD2 (1992); 2.2.1.1 The Structure; 2.2.1.2 What We Learnt; 2.2.2 Human sCD2 (1994); 2.2.2.1 The Structure; 2.2.2.2 What We Learnt; 2.2.3 The Role of Charged Residues in Ligand Binding by CD2 (1998); 2.2.3.1 Mutational Analysis of Rat CD2; 2.2.3.2 What We Learnt; 2.2.4 CD58 d1 (1999); 2.2.4.1 The Structure; 2.2.4.2 What We Learnt; 2.2.5 CD48 d1 (2006); 2.2.5.1 The Structure; 2.2.5.2 What We Learnt. 2.3 Cell-Cell Recognition and Costimulation: CD28 Family Proteins2.3.1 sB7-1 (2000); 2.3.1.1 The Structure; 2.3.1.2 What We Learnt; 2.3.2 sCTLA-4/sB7-1 Complex (2001); 2.3.2.1 The Structure; 2.3.2.2 What We Learnt; 2.3.3 sCD28/5.11A1 Antibody Fab (2005); 2.3.3.1 The Structure; 2.3.3.2 What We Learnt; 2.3.4 sCTLA-4 (2011); 2.3.4.1 The Structure; 2.3.4.2 What We Learnt; 2.3.5 sPD-1 (2013); 2.3.5.1 The Structure and Interactions; 2.3.5.2 What We Learnt; 2.4 Concluding Remarks; Acknowledgments; References; Chapter 3: Synthetic Antibody Engineering: Concepts and Applications; 3.1 Introduction. 3.2 Immunoglobulin Structure and Function3.3 Engineering Phage-Displayed Antibody Libraries; 3.4 Applications; 3.4.1 Engineering of Conformation-Specific Antibodies; 3.4.2 Engineering of Cross-Reactive Antibodies; 3.4.3 Engineering of Antibodies Specific for Point-Mutants and PTMs; 3.5 Conclusions; References; Chapter 4: Natural Killer Cell Receptors; 4.1 Introduction; 4.2 MHC-I Recognition by Ly49 Receptors; 4.3 Ly49 Receptors Interact With MHC-I in Trans and Cis; 4.4 Ly49A's Recognition of a Viral Immunoevasin; 4.5 Recognition of MHC-I by KIR Receptors; 4.6 Recognition of MHC-I by LILRs. Includes bibliographical references and index. Immunology. Biomolecules Structure. Molecular biology. Allergy and Immunology. (DNLM)D000486 Molecular Biology. (DNLM)D008967 HEALTH & FITNESS Diseases General. bisacsh MEDICAL Clinical Medicine. bisacsh MEDICAL Diseases. bisacsh MEDICAL Evidence-Based Medicine. bisacsh MEDICAL Internal Medicine. bisacsh Biomolecules Structure. fast (OCoLC)fst00832635 Immunology. fast (OCoLC)fst00968006 Molecular biology. fast (OCoLC)fst01024734 Electronic books. Electronic books. Putterman, Chaim, editor. Cowburn, David, editor. Almo, Steven, editor. Print version: Structural biology in immunology. London, United Kingdom : Academic Press, an imprint of Elsevier, [2018] 9780128033692 012803369X (OCoLC)992433771 ScienceDirect https://www.sciencedirect.com/science/book/9780128033692 ScienceDirect https://www.sciencedirect.com/book/9780128033692