05881cam a2200601Ii 4500 on1025341174 OCoLC 20210423014324.0 m o d cr cnu|||unuuu 180228s2018 ne a ob 001 0 eng d N$T eng rda pn N$T EBLCP N$T OPELS YDX NLE OCLCF UAB SNK D6H OCLCQ INT OCLCQ U3W LVT OCLCQ UKMGB OCLCQ S2H OCLCO GBB803845 bnb 018668616 Uk 1027153107 1027302774 1027618173 1027714502 1027768912 1027824404 1028036091 1028080154 1028208421 1028525664 9780128145968 (electronic bk.) 012814596X (electronic bk.) 9780128145951 0128145951 (OCoLC)1025341174 (OCoLC)1027153107 (OCoLC)1027302774 (OCoLC)1027618173 (OCoLC)1027714502 (OCoLC)1027768912 (OCoLC)1027824404 (OCoLC)1028036091 (OCoLC)1028080154 (OCoLC)1028208421 (OCoLC)1028525664 RB52.5 MED 075000 bisacsh SCI 036000 bisacsh 612.3/13 23 White, Robert M., 1945- author. Detection of drugs and their metabolites in oral fluid / Robert M. White, Sr., Christine M. Moore. Amsterdam, Netherlands : Elsevier, [2018] 1 online resource : illustrations (some color) text txt rdacontent computer c rdamedia online resource cr rdacarrier Emerging issues in analytical chemistry Includes bibliographical references and index. Vendor-supplied metadata. Front Cover; Detection of Drugs and Their Metabolites in Oral Fluid; Copyright Page; Dedication; Contents; Preface; Acknowledgments; 1 Introduction; General; Disease States That May Influence Salivary Function; The Influence of Drugs on Salivary Function; References; 2 Oral Fluid Pharmacokinetics; Introduction; Ethanol; Ethyl Alcohol, â#x80;#x9C;Alcoholâ#x80;#x9D;; Cannabinoids; Cocaine; Amphetamines; Methamphetamine; Methylenedioxymethamphetamine; Opiates; Codeine, Morphine, and Diacetylmorphine; Hydrocodone; Oxycodone; Benzodiazepines; Other Drugs; Phencyclidine; Methadone; Fentanyl; Nicotine. New Psychoactive SubstancesReferences; 3 Collection of Oral Fluid; Introduction; Neat Oral Fluid; Advantages; Disadvantages; Saliva Collection System; Pad, No Buffer; Advantages; Disadvantages; Pad and Buffer; Advantages; Disadvantages; Summary; References; 4 Point of Collection Testing; Introduction; Evaluation; Specific Applications; Driving Under the Influence of Drugs; Clinical Applications; References; 5 Initial Testing; Introduction; Sensitivity; Cross-Reactivity; Chromatographyâ#x80;#x93;Mass Spectrometry; Conclusions; References; 6 Specimen Validity Testing; Introduction; Oral Fluid SVT. ConclusionReferences; 7 Confirmatory Testing; Introduction; Separation; Method Validation; Sensitivity; Major Drug Classes; Amphetamines; Cocaine; Cannabis; Benzodiazepines; Opioids; Phencyclidine; Novel Psychoactive Substances; Derivatization in LC-MS; Chiral Separation of Amphetamine and Methamphetamine; Improved Sensitivity for THC-COOH in Oral Fluid; Improved Sensitivity for 11-OH-THC in Oral Fluid; Summary; References; 8 Interlaboratory Comparison; Introduction; Commercial Controls; Blind Controls; Internally Submitted; Externally Submitted; Proficiency Testing. SAMHSA Oral Fluid Pilot PT ProgramCollege of American Pathologists; RTI Proficiency Testing Program for Alcohol and Drugs in Oral Fluid; Performance Testing; Summary; References; 9 Individual Analytes, Specimen Handling, Stability, and Other Issues; Introduction; Oral Fluid; Î#x94;9-Tetrahydrocannabinol; Cocaine; Amphetamines; Opiates; Benzodiazepines; References; 10 Concluding Remarks; Strengths of Oral Fluid as a Test Matrix; Weaknesses of Oral Fluid as a Test Matrix; Methodological Needs; Cutting-Edge Trends; Summary; Index; Back Cover. Detection of Drugs and Their Metabolites in Oral Fluid presents the analytical chemistry methods used for the detection and quantification of drugs and their metabolites in human oral fluid. The authors summarize the state of the science, including its strengths, weaknesses, unmet methodological needs, and cutting-edge trends. This volume covers the salient aspects of oral fluid drug testing, including specimen collection and handling, initial testing, point of collection testing (POCT), specimen validity testing (SVT), and confirmatory and proficiency testing. Analytes discussed include amphetamines, cannabinoids, cocaine, opiates, phencyclidine, cannabimimetics, and miscellaneous drugs. This practical guide helps users turn knowledge into practice, moving logically from an outline of the problem, to the evaluation of the appropriateness of oral fluid as a test medium, and finally to a consideration of detection methods and their validation and employment. Saliva Analysis. Saliva Examination. Drug testing. MEDICAL Physiology. bisacsh SCIENCE Life Sciences Human Anatomy & Physiology. bisacsh Drug testing. fast (OCoLC)fst00898710 Saliva Analysis. fast (OCoLC)fst01104051 Saliva Examination. fast (OCoLC)fst01104052 Electronic books. Electronic books. Moore, Christine M., author. Print version: White, Robert M., 1945- Detection of drugs and their metabolites in oral fluid. Amsterdam, Netherlands : Elsevier, [2018] 0128145951 9780128145951 (OCoLC)993644293 Emerging issues in analytical chemistry. ScienceDirect https://www.sciencedirect.com/science/book/9780128145951