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|a 9789813347618
|9 978-981-33-4761-8
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|a 10.1007/978-981-33-4761-8
|2 doi
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|a Qidwai, Tabish.
|e author.
|4 aut
|4 http://id.loc.gov/vocabulary/relators/aut
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|a Exploration of Host Genetic Factors associated with Malaria
|h [electronic resource] /
|c by Tabish Qidwai.
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|a 1st ed. 2021.
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|a Singapore :
|b Springer Singapore :
|b Imprint: Springer,
|c 2021.
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| 300 |
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|a XI, 172 p. 79 illus., 48 illus. in color.
|b online resource.
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|a text
|b txt
|2 rdacontent
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|a computer
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|2 rdamedia
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|a online resource
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|a text file
|b PDF
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|a Chapter 1. Human genetics and infectious disease -- Part 1. RBC disorders -- Chapter 2. Sickle cell gene -- Chapter 3. Alpha-Thalassemia -- Chapter 4. Beta-Thalassemia -- Chapter 5. Duffy blood group locus -- Part 2. Metabolic enzymes -- Chapter 6. Pyruvate kinase deficiency -- Chapter 7. Glucose 6-Phosphate dehydrogenase -- Part 3. Host immune response -- Chapter 8. TNF genetic polymorphisms -- Chapter 9. iNos genetic polymorphisms -- Chapter 10. Human complement receptor 1 polymorphisms -- Chapter 11. Interferonalpha receptor-1 (IFNAR1) polymorphisms -- Part 4. Cytoadherence -- Chapter 12. Intercellular adhesion molecule-1 polymorphisms -- Chapter 13. Platelet endothelial cell adhesion molecule-1 (PECAM-1) polymorphisms -- Chapter 14. Vascular cell adhesion molecule-1 (VCAM1) polymorphisms.
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|a This book is aimed to cover the role of genetic polymorphisms in human genes related to RBC disorders, metabolic enzymes, immune response, and cytoadherence in the susceptibility/resistance to malaria caused by Plasmodium falciparum. The chapters provide current information on the balancing trait and the significance of such traits in the malaria resistance. The book covers polymorphisms in the genes of the red blood cells-sickle cell anaemia; glucose-6-phosphate dehydrogenase deficiency and thalassemia that confer protection against malaria. In addition, the book explores selection of genetic variations in the human genome as genetic control mechanism against malaria in endemic regions. It also provides a comprehensive overview of the molecular epidemiology and natural selection of alleles in the genes which are associated with malaria, and presents description of the role of human genetic polymorphisms in malaria disease risk and disease outcome.
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|a Human genetics.
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|a Infectious diseases.
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|a Parasitology.
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|a Immunology.
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|a Human Genetics.
|0 https://scigraph.springernature.com/ontologies/product-market-codes/B12008
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| 650 |
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|a Infectious Diseases.
|0 https://scigraph.springernature.com/ontologies/product-market-codes/H33096
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| 650 |
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|a Parasitology.
|0 https://scigraph.springernature.com/ontologies/product-market-codes/B19002
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| 650 |
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|a Immunology.
|0 https://scigraph.springernature.com/ontologies/product-market-codes/B14000
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| 710 |
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|a SpringerLink (Online service)
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|t Springer Nature eBook
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| 776 |
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|i Printed edition:
|z 9789813347601
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| 776 |
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|i Printed edition:
|z 9789813347625
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|i Printed edition:
|z 9789813347632
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|u https://doi.org/10.1007/978-981-33-4761-8
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|a ZDB-2-SBL
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|a ZDB-2-SXB
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|a Biomedical and Life Sciences (SpringerNature-11642)
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|a Biomedical and Life Sciences (R0) (SpringerNature-43708)
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