03995nam a22005295i 4500 978-981-10-5526-3 DE-He213 20210619003620.0 cr nn 008mamaa 180628s2018 si | s |||| 0|eng d 9789811055263 978-981-10-5526-3 10.1007/978-981-10-5526-3 doi QP34-38 MFG bicssc MED075000 bisacsh MFG thema 612 23 Developmental Origins of Health and Disease (DOHaD) [electronic resource] : From Biological Basis to Clinical Significance / edited by Takeo Kubota, Hideoki Fukuoka. 1st ed. 2018. Singapore : Springer Singapore : Imprint: Springer, 2018. VII, 95 p. 23 illus., 16 illus. in color. online resource. text txt rdacontent computer c rdamedia online resource cr rdacarrier text file PDF rda Advances in Experimental Medicine and Biology, 0065-2598 ; 1012 Part 1 Biological Basis -- One carbon metabolism and lipid metabolism in DOHaD -- Novel models of epigenetic gene regulation in the nutritional environment -- Epigenetic switching and neonatal nutritional environment -- Part 2 Disease and environment -- Developmental Origins of Non-Alcoholic Fatty Liver Disease (NAFLD) -- Fetal origins of hypertension -- Involvement of noncoding RNAs in stress-related neuropsychiatric diseases caused by DOCaD theory -- Part 3 Transgenerational mechanism and its consequences -- Placental development and nutritional environment -- Risk of neurodevelopmental disease by paternal aging: a possible influence of epigenetic alteration in sperm -- Part 4 Clinical Significance -- Preemptive epigenetic medicine based on fetal programming. This book addresses the developmental origins of health and disease (DOHaD), a new medical concept that demonstrates that various adult diseases start in the fetal period. It discusses our current understanding of the molecular mechanisms of DOHaD, including gene body epigenetics and non-coding RNA, and comprehensively examines diseases such type 2 diabetes, a well known as standard DOHaD-associated disease, as well as non-alcoholic fatty liver disease, hypertension and neurodevelopmental disorders. It argues that most adult diseases start at a very early stage, such as in the fetal and neonatal periods, and that earlier prevention and intervention would result in better outcomes for adult diseases such as type 2 diabetes and cardiac disorders, which are increasing in both developed and developing countries. The book appeals to obstetricians and pediatricians, as well as physicians who treat adult patients, wanting to understand the origins of diseases. Human physiology. Reproductive medicine. Developmental biology. Human Physiology. https://scigraph.springernature.com/ontologies/product-market-codes/B13004 Reproductive Medicine. https://scigraph.springernature.com/ontologies/product-market-codes/H56002 Developmental Biology. https://scigraph.springernature.com/ontologies/product-market-codes/L18000 Kubota, Takeo. editor. edt http://id.loc.gov/vocabulary/relators/edt Fukuoka, Hideoki. editor. edt http://id.loc.gov/vocabulary/relators/edt SpringerLink (Online service) Springer Nature eBook Printed edition: 9789811055256 Printed edition: 9789811055270 Printed edition: 9789811338564 Advances in Experimental Medicine and Biology, 0065-2598 ; 1012 https://doi.org/10.1007/978-981-10-5526-3 ZDB-2-SBL ZDB-2-SXB Biomedical and Life Sciences (SpringerNature-11642) Biomedical and Life Sciences (R0) (SpringerNature-43708)