04670nam a22005415i 4500 978-3-319-18326-8 DE-He213 20210701164731.0 cr nn 008mamaa 150609s2015 gw | s |||| 0|eng d 9783319183268 978-3-319-18326-8 10.1007/978-3-319-18326-8 doi R-RZ MBGR bicssc MED000000 bisacsh MBGR thema 610 23 Life Extension [electronic resource] : Lessons from Drosophila / edited by Alexander M. Vaiserman, Alexey A. Moskalev, Elena G. Pasyukova. 1st ed. 2015. Cham : Springer International Publishing : Imprint: Springer, 2015. VIII, 353 p. 49 illus., 26 illus. in color. online resource. text txt rdacontent computer c rdamedia online resource cr rdacarrier text file PDF rda Healthy Ageing and Longevity, 2199-9007 ; 3  Preface -- SECTION I: Genetic regulation of longevity -- Mutations and quantitative genetic variation: lessons from Drosophila -- Modulation of Drosophila lifespan by neuronal genes -- Life span, stress resistance and age-dependent transcriptome dynamics in fruit flies with constitutive and conditional overexpression of GADD45 -- Superoxide dismutase over-expression and the mitochondrial unfolded protein response -- Effect of Wolbachia infection on aging and longevity-associated genes in Drosophila -- SECTION II: Drosophila models for aging-associated diseases -- Skeletal muscle homeostasis and aging -- Drosophila models of cardiac disease -- Genetic modulation of cardiac functional aging -- Functional links between circadian clocks, redox state and aging in Drosophila -- Drosophila models in therapeutic drug discovery -- SECTION III: Life-extending treatments -- Phytochemicals with lifespan extension effect in Drosophila -- Life extension in Drosophila by inhibitors of histone deacetylases -- Drosophila healthspan extension using dietary manipulation -- The effect of the artificial atmosphere on the flies’ longevity -- Effects of several mild stresses applied in adults on aging and longevity -- Life extension via stage-specific drug interventions in Drosophila -- Index. This book looks at aging through research on Drosophila, the fruit fly that is one of the most widely used model organisms in biogerontology. Work in model organisms can expand the theoretical knowledge of aging: it yields valuable insight into the molecular and cellular processes that underlie aging process, and it can perhaps provide new therapeutic targets for the treatment of age-related disorders in humans. Drosophila models have been developed for a large variety of aging-related processes and diseases, and this book provides readers with an overview of current research on the use of the Drosophila model to understand the genetic, molecular and physiological mechanisms that underlie the aging process. Themes of healthspan, life extension and longevity-associated genes emerge in this collation of international research on Drosophila that is of relevance to geriatrics and gerontology, animal genetics and genomics, and biomedicine. This fascinating, illustrated book will be of interest to a wide audience, ranging from academic researchers to the general reader.  . Medicine. Animal genetics. Geriatrics. Biomedicine, general. https://scigraph.springernature.com/ontologies/product-market-codes/B0000X Animal Genetics and Genomics. https://scigraph.springernature.com/ontologies/product-market-codes/L32030 Geriatrics/Gerontology. https://scigraph.springernature.com/ontologies/product-market-codes/H33150 Vaiserman, Alexander M. editor. edt http://id.loc.gov/vocabulary/relators/edt Moskalev, Alexey A. editor. edt http://id.loc.gov/vocabulary/relators/edt Pasyukova, Elena G. editor. edt http://id.loc.gov/vocabulary/relators/edt SpringerLink (Online service) Springer Nature eBook Printed edition: 9783319183275 Printed edition: 9783319183251 Printed edition: 9783319382104 Healthy Ageing and Longevity, 2199-9007 ; 3 https://doi.org/10.1007/978-3-319-18326-8 ZDB-2-SBL ZDB-2-SXB Biomedical and Life Sciences (SpringerNature-11642) Biomedical and Life Sciences (R0) (SpringerNature-43708)