04459nam a22005415i 4500 978-3-030-62532-0 DE-He213 20210622235812.0 cr nn 008mamaa 210129s2020 gw | s |||| 0|eng d 9783030625320 978-3-030-62532-0 10.1007/978-3-030-62532-0 doi RB155-155.8 QH431 MFN bicssc MED107000 bisacsh MFN thema 611.01816 23 599.935 23 Human Interphase Chromosomes [electronic resource] : Biomedical Aspects / edited by Ivan Iourov, Svetlana Vorsanova, Yuri Yurov. 2nd ed. 2020. Cham : Springer International Publishing : Imprint: Springer, 2020. XII, 178 p. 39 illus., 34 illus. in color. online resource. text txt rdacontent computer c rdamedia online resource cr rdacarrier text file PDF rda Human Interphase Cytogenomics -- Eukaryotic genome in three dimensions -- Analysis of cell and nucleus genome by Next-Generation Sequencing -- Interphase Chromosomes of the Human Brain -- Senescence and the Genome -- Unclassified Chromosome Abnormalities and Genome Behavior in Interphase -- 21st century FISH: focus on interphase chromosomes -- Chromosome architecture studied by high resolution FISH-banding in three dimensionally preserved human interphase nuclei -- Chromosome-centric Look at the Genome -- Index. This second edition focuses on the study of human interphase chromosomes and its relation to health and disease. Orchestrated organization and behavior of the human genome in interphase nuclei at chromosomal level has been repeatedly shown to play a significant role in almost all basic biological processes involved in the processing and inheritance of genetic information within and between species. Accordingly, post-genomic bioscience appeals to basic and applied studies of interphase nuclei genetics and genomics with special attention to interphase chromosome behavior in health and disease. Additionally, elucidating the role of interphase chromosome behavior during development, chromosome/DNA replication, DNA reparation opens new horizons for basic and applied bioscience Studies of interphase nuclei have an appreciable impact on different areas of biomedical sciences such as cell biology, neurobiology, cancer research, developmental biology, epigenetics, cytogenetics, and medical genetics, as a whole. Moreover, development of innovative and emergent technologies to analyze interphase nuclei are closely associated with application of these techniques in diagnostic and research practices to solve reproductive problems (including infertility and spontaneous abortions), to investigate congenital malformations (including those produced by aneuploidy and other chromosome abnormalities); genetic diseases (including cardiac, immune, neurological and psychiatric diseases), and cancer. This second edition serves as a source of updated valuable information and promising ideas for a wide audience of professionals in biomedicine including researchers, scientists, and healthcare professionals in human genetics, cytogenetics, and developmental biology. Human genetics. Cytogenetics. Cell biology. Human Genetics. https://scigraph.springernature.com/ontologies/product-market-codes/B12008 Cytogenetics. https://scigraph.springernature.com/ontologies/product-market-codes/B12040 Cell Biology. https://scigraph.springernature.com/ontologies/product-market-codes/L16008 Iourov, Ivan. editor. edt http://id.loc.gov/vocabulary/relators/edt Vorsanova, Svetlana. editor. edt http://id.loc.gov/vocabulary/relators/edt Yurov, Yuri. editor. edt http://id.loc.gov/vocabulary/relators/edt SpringerLink (Online service) Springer Nature eBook Printed edition: 9783030625313 Printed edition: 9783030625337 Printed edition: 9783030625344 https://doi.org/10.1007/978-3-030-62532-0 ZDB-2-SBL ZDB-2-SXB Biomedical and Life Sciences (SpringerNature-11642) Biomedical and Life Sciences (R0) (SpringerNature-43708)