03486nam a22005295i 4500 978-3-030-31053-0 DE-He213 20210620071134.0 cr nn 008mamaa 190903s2019 gw | s |||| 0|eng d 9783030310530 978-3-030-31053-0 10.1007/978-3-030-31053-0 doi QR180-189.5 MJCM bicssc MED044000 bisacsh MJCM thema 616.079 23 Fc Mediated Activity of Antibodies [electronic resource] : Structural and Functional Diversity / edited by Jeffrey V. Ravetch, Falk Nimmerjahn. 1st ed. 2019. Cham : Springer International Publishing : Imprint: Springer, 2019. VII, 150 p. 14 illus., 12 illus. in color. online resource. text txt rdacontent computer c rdamedia online resource cr rdacarrier text file PDF rda Current Topics in Microbiology and Immunology, 0070-217X ; 423 IgG Fc receptors: evolutionary considerations -- Role of FcgRs in Antibody Based Cancer Therapy -- Anti-inflammatory Activity of IgG-Fc -- IgG Fc glycosylation in human immunity -- IgE Glycosylation in Health and Disease -- Immune Complex Vaccination -- Fc receptors in anti-microbial protection. This volume explores several aspects of how antibodies mediate their activity in vivo, ranging from cancer immunotherapy to autoimmunity, infection, and vaccination. Divided into seven chapters, it provides in-depth insights into how antibodies and especially the antibody fragment crystallizable (Fc) domain modulate immune responses and antibody activity. The book begins by discussing evolutionary aspects of how the family of Fc receptors that are the key molecules for antibody activity evolved. In turn, it addresses the molecular and cellular pathways underlying IgG activity in cancer immunotherapy, and focuses on how IgG glycosylation regulates IgG and IgE activity in autoimmunity, allergy and infection. In closing, it presents strategies for developing novel antibody-based vaccination approaches. The book is intended for a very broad readership, including graduate students, postdocs and principal investigators with a basic grasp of immunology. Immunology. Cancer research. Infectious diseases. Immunology. https://scigraph.springernature.com/ontologies/product-market-codes/B14000 Cancer Research. https://scigraph.springernature.com/ontologies/product-market-codes/B11001 Infectious Diseases. https://scigraph.springernature.com/ontologies/product-market-codes/H33096 Ravetch, Jeffrey V. editor. edt http://id.loc.gov/vocabulary/relators/edt Nimmerjahn, Falk. editor. edt http://id.loc.gov/vocabulary/relators/edt SpringerLink (Online service) Springer Nature eBook Printed edition: 9783030310523 Printed edition: 9783030310547 Printed edition: 9783030310554 Current Topics in Microbiology and Immunology, 0070-217X ; 423 https://doi.org/10.1007/978-3-030-31053-0 ZDB-2-SBL ZDB-2-SXB Biomedical and Life Sciences (SpringerNature-11642) Biomedical and Life Sciences (R0) (SpringerNature-43708)