04014nam a22005415i 4500 978-1-4939-2895-8 DE-He213 20210623141357.0 cr nn 008mamaa 150727s2015 xxu| s |||| 0|eng d 9781493928958 978-1-4939-2895-8 10.1007/978-1-4939-2895-8 doi QH345 QD415-436 PSB bicssc SCI007000 bisacsh PSB thema 572 23 Glucocorticoid Signaling [electronic resource] : From Molecules to Mice to Man / edited by Jen-Chywan Wang, Charles Harris. 1st ed. 2015. New York, NY : Springer New York : Imprint: Springer, 2015. XI, 385 p. 36 illus., 29 illus. in color. online resource. text txt rdacontent computer c rdamedia online resource cr rdacarrier text file PDF rda Advances in Experimental Medicine and Biology, 0065-2598 ; 872 Section I: Introductory Materials -- Regulatory actions of glucocorticoid hormones: from organisms to mechanisms.-  Molecular Biology of  Glucocorticoid Signaling.-Mechanisms of Glucocorticoid-regulated Gene Transcription -- Clinical Perspective: What do Addison and Cushing tell us about Glucocorticoid Action? -- Section II: Effects of Glucocorticoids in Metabolism -- Regulation of Glucose Homeostasis by Glucocorticoids -- How do Glucocorticoids Regulate Lipid Metabolism? -- Glucocorticoids and Skeletal Muscle -- Section III: Specific Effects of Glucocorticoids on Tissues -- Glucocorticoid- induced osteoporosis -- Effects of Glucocorticoids on Immune System -- Glucocorticoids and the brain: neural mechanisms regulating the stress response -- Glucocorticoid Regulation of Reproduction -- Glucocorticoids and the lung -- Glucocorticoids and the Cardiovascular System -- Glucocorticoids and Cancer -- Section IV: Miscellaneous Topics -- Animal Models of Altered Glucocorticoid Signaling -- The Dehydrogenase Hypothesis -- Conclusions and Future Directions. This timely volume provides a comprehensive overview of glucocorticoids and their role in regulating many aspects of physiology and their use in the treatment of disease. The book is broken into four sections that begin by giving a general introduction to glucocorticoids and a brief history of the field. The second section will discuss the effects of glucocorticoids on metabolism, while the third section will cover the effects of glucocorticoids on key tissues. The final section will discuss general topics, such as animal models in glucocorticoid research and clinical implications of glucocorticoid research. Featuring chapters from leaders in the field, this volume will be of interest to both researchers and clinicians. Biochemistry. Endocrinology . Human physiology. Biochemistry, general. https://scigraph.springernature.com/ontologies/product-market-codes/L14005 Endocrinology. https://scigraph.springernature.com/ontologies/product-market-codes/H33053 Human Physiology. https://scigraph.springernature.com/ontologies/product-market-codes/B13004 Wang, Jen-Chywan. editor. edt http://id.loc.gov/vocabulary/relators/edt Harris, Charles. editor. edt http://id.loc.gov/vocabulary/relators/edt SpringerLink (Online service) Springer Nature eBook Printed edition: 9781493928941 Printed edition: 9781493928965 Printed edition: 9781493949977 Advances in Experimental Medicine and Biology, 0065-2598 ; 872 https://doi.org/10.1007/978-1-4939-2895-8 ZDB-2-SBL ZDB-2-SXB Biomedical and Life Sciences (SpringerNature-11642) Biomedical and Life Sciences (R0) (SpringerNature-43708)