04428nam a22005895i 4500 978-1-4614-7678-8 DE-He213 20210615191238.0 cr nn 008mamaa 130808s2013 xxu| s |||| 0|eng d 9781461476788 978-1-4614-7678-8 10.1007/978-1-4614-7678-8 doi QH505 PHVN bicssc SCI009000 bisacsh PHVN thema PHVD thema 571.4 23 Biophysics of the Failing Heart [electronic resource] : Physics and Biology of Heart Muscle / edited by R. John Solaro, Jil C. Tardiff. 1st ed. 2013. New York, NY : Springer New York : Imprint: Springer, 2013. VI, 253 p. online resource. text txt rdacontent computer c rdamedia online resource cr rdacarrier text file PDF rda Biological and Medical Physics, Biomedical Engineering, 1618-7210 Chapter 1 Introduction to the Biophysics of the Failing Heart -- Chapter 2 Sarcoplasmic reticulum Ca homeostasis and Heart Failure -- Chapter 3 Ca-homeostasis and Heart Failure: Focus on the Biophysics of Surface Membrane Ca-Fluxes -- Chapter 4 Biophysics of Membrane Currents in Heart Failure -- Chapter 5 Biophysical Mechanisms for the Metabolic Component of Impaired Heart Function -- Chapter 6 Cytoskeletal Nuclear Links in the Cardiomyocyte -- Chapter 7 Biophysical Forces Modulate the Costamere and Z-Disc -- Chapter 8 Heart failure- the final frontier for biophysics in cardiovascular medicine? -- Chapter 9 Arrhythmogenesis, Heart Failure, and the Biophysics of Z-band Protein Networks -- Chapter 10 Biophysics of Titin in Cardiac Health and Disease -- Chapter 11 Sarcomeres and the Biophysics of Heart Failure -- Index. Biophysics of the Failing Heart considers major biophysical mechanisms for why hearts responding to stressors enter into maladaptive processes, eventually leading to an inability of the heart to respond efficiently to hemodynamic loads--especially during exercise. The book describes biophysical techniques that have been applied to determine the triggers for the heart failure process, as well as the mechanisms for sustaining the disorders. These techniques include measurements of active and passive mechanical properties and hemodynamics at levels of organization ranging from molecules to hearts beating in situ. Biophysical concepts and approaches are also applied to determination of signaling and signal transduction, energetics, ionic currents, transport processes, electro-chemical and chemo-mechanical coupling. Modern research approaches and clinical understanding of heart failure demands integration of multiple aspects of the disorders. By its emphasis on biophysical aspects of a prevalent clinical condition, this monograph is unique in its perspective and focus, and will be of value to clinicians and researchers at all levels. Biophysics. Biological physics. Cardiology. Medical physics. Radiation. Biomedical engineering. Biological and Medical Physics, Biophysics. https://scigraph.springernature.com/ontologies/product-market-codes/P27008 Cardiology. https://scigraph.springernature.com/ontologies/product-market-codes/H33037 Medical and Radiation Physics. https://scigraph.springernature.com/ontologies/product-market-codes/P27060 Biomedical Engineering and Bioengineering. https://scigraph.springernature.com/ontologies/product-market-codes/T2700X Solaro, R. John. editor. edt http://id.loc.gov/vocabulary/relators/edt Tardiff, Jil C. editor. edt http://id.loc.gov/vocabulary/relators/edt SpringerLink (Online service) Springer Nature eBook Printed edition: 9781493901852 Printed edition: 9781461476771 Printed edition: 9781461476795 Biological and Medical Physics, Biomedical Engineering, 1618-7210 https://doi.org/10.1007/978-1-4614-7678-8 ZDB-2-PHA ZDB-2-SXP Physics and Astronomy (SpringerNature-11651) Physics and Astronomy (R0) (SpringerNature-43715)